Population Structure Shapes Copy Number Variation in Malaria Parasites
نویسندگان
چکیده
منابع مشابه
Adaptive Copy Number Evolution in Malaria Parasites
Copy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to which this reflects the action of positive selection is poorly understood. The first gene in the Plasmodium folate biosynthesis pathway, GTP-cyclohydrolase I (gch1), shows extensive CNP. We provide compelling evidence that gch1 CNP is an adaptive consequence of selection by antifolate drugs, which target enzym...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2015
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msv282